What is this coenzyme Q10 that everyone is talking about?

April 01, 2022

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COENZYME Q10, Coenzyme Q10, molecular formula C59H90O4, CAS No. 303-98-0, molecular weight 863.344, density 1.0 ± 0.1 g/cm3, boiling point 869.0 ± 65.0 ° C at 760 MMHG, melting point 49-51 ° C.

At Room temperature, coq10 is a yellow-orange crystalline powder, an important cofactor for electron transport chain, an effective fat-soluble antioxidant and an essential member of the respiratory chain in all cellular Mitochondria. COENZYME Q10 is located in Mitochondria, lysosomes, Golgi apparatus and plasma membranes and provides antioxidation by direct reaction with free radicals or by regeneration of tocopherols and ascorbic acid from their oxidized state.

COQ10 is a popular dietary supplement. It is widely used in nutrition and health care products and food additives at home and abroad, and widely used in cardiovascular system diseases in medicine. For example:

1.It can reduce the reduction of myocardial contractility and the content of N-phosphocreatine and Adenosine triphosphate during Acute Ischemia, maintain the morphological structure of Mitochondria of ischemic myocardial cells, and have certain protective effect on ISCHEMIC myocardium.

2. Increasing cardiac output and reducing peripheral resistance may be beneficial to the treatment of heart failure, and may inhibit the synthesis and secretion of aldosterone and block its effect on Renal tubules.

3. The action potential duration was shortened and the threshold of ventricular Arrhythmia was higher than that of the control animals when the isolated ventricular muscle was perfused under hypoxia.

4. It can reduce the resistance of peripheral blood vessels and has the effect of anti-aldosterone.

5. COQ10 has anti-doxorubicin cardiotoxicity and liver protection.

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